"Fare a pugni con se stessi" is an Italian expression that translates to "to fight with oneself" or "to struggle with oneself" in English. 
It's used to describe the internal conflict or struggle that someone experiences within themselves and is the basis of the creative process that led to this illustration.
The best treatment for depression? It could be excercise
"Exercise as a treatment for severe depression is at least as effective as standard drugs or psychotherapy and by some measures better, according to the largest study to date of exercise as “medicine” for depression." 
by G.Reynolds - The Washington Post
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